Numerical Simulation of Blood Flow Mixed with Magnetic Nanoparticles under the Influence of AC and DC Magnetic Field

Document Type : Research Paper


1 K.N Toosi University

2 Mechanical Engineering Departmen, K. N. Toosi University of Technology, Tehran, Iran

3 Mechanical Engineering Department, K.N. Toosi University of technology, Tehran, Iran


Nanoparticles combined with magnetic fields are one of the most important research areas in the field of biomedical engineering. Direct Current (DC) magnetic and Alternative Current (AC) magnetic fields are often used for controlling nanoparticles. It is also used for hyperthermia treatment. The purpose of the current study is to investigate the effect of DC and AC magnetic field on nanoparticles mixed with biofluid (non-Newtonian blood).The coupled nonlinear equations continuity, momentum, concentration and energy are solved with finite volume code. Results show that increase in blood temperature doesn’t influence the nanoparticles concentration as well as the velocities and pressure distribution of bloodinside the channel. In addition results show that the DC magnetic field absorbs magnetic nanoparticles and the AC magnetic field induces energy into nanoparticles. Also the eddy current, as the only source of energy in this study, doesn’t change the blood flow temperature. Finally it is shown that magnetic nanoparticles mixed with magnetic fields are a good tool for medical applications.


Main Subjects

[1] Tartaj, P., "The Preparation of Magnetic Nanoparticles for Applications in Biomedicine", J. of Phy, Vol. 36, No. 13, pp. 182-197, (2003).
[2]Farokhzad,O.C, "Targeted Nanoparticle-Aptamer Bioconjugates for Cancer Chemotherapy in Vivo", Proc. Natl. Acad. Sci. U. S. A. Vol. 103, No. 16, pp. 6315–6320, (2006).
[3] Li, X.L,"CFD Study on the Magnetic Fluid Delivering in the Vessel in High-gradient Magnetic Field", Journal of Magnetism and Magnetic Materials, Vol. 320, pp. 1753–1758, (2008).
[4] Habibi, M.R., and Ghassemi, M., "Numerical Study of Magnetic Nanoparticles Concentration in Biofluid (Blood) under the Influence of High Gradient Magnetic Field", Journal of Magnetism and Magnetic Materials, Vol. 323, pp. 32–38, (2011).
[5] Habibi, M.R., Ghassemi, M., and Hamedi, M.H., "Analysis of  High Gradient Magnetic Field Effects on Distribution of  Nanoparticles Injected into Pulsatile Blood Stream", Journal of Magnetism and Magnetic Materials, Vol. 324, pp. 1473–1482,( 2012).
[6] Berthier, J., "Microfluidics for Biotechnology", John Wiely and Sons, New York, (2006).
[7] Rosensweig, R. E., "Heating Magnetic Fluid with Alternating Magnetic Feld", Journal of Magnetism and Magnetic Materials, Vol. 252, pp. 370–374, (2002).
[8] Zhai, Z., "Magnetic Induction Heating of Nano Sized Ferrite Particle", Advances in Induction and Microwave Heating of Mineral and Organic Materials, Ed. In Tech, Vol. 21, No. 8, pp. 484-500,( 2011).
[9] Ivkovet, R., "Applicationof  High Amplitude Alternating Magnetic Fields for Heat Induction of  Nanoparticles Localized in Cancer", Clinical Cancer Research, Vol. 11, 7093s., (2005).
[10] Cervadoroet., A., "Design Maps for the Hyperthermic Treatment of Tumors with Superparamagnetic Nanoparticles", PLoS One, Vol. 8, No. 2, pp. 237-250, (2013).
[11] Ghassemi, M., Shahidian, A., Ahmadi. G., and Hamian, S., "A New Effective Thermal Conductivity  Model for a Bio-nanofluid (Blood with Nanoparticle Al2O3)", International Journal of Heat and Mass Transfer, Vol. 37, pp. 929–934,(2010).
[12] Smith,  J., and Wijn, H., "Ferrites", Clever-Hume Press Ltd, London, (1959).
[13] Latif, M., "Heat Convection ", Springer, New York, (2006).