Ionic Channel Blockage Effect on the Electromechanical Model of Human Gastric Wall Smooth Muscle Cells

Document Type : Research Paper


1 Ph.D., Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran,

2 Corresponding Author, Professor, Pediatric Neurorehabilitation Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran,

3 Associate Professor, Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran,

4 Associate Professor, Department of Electrical and Computer Engineering, New York Institute of Technology, Old Westbury, New York, USA,


In this paper, a three-dimensional electromechanical model is presented to investigate the effect of calcium and potassium ionic channels on the contractile behavior of human gastric wall smooth muscle cells with the finite element approach. In this model, simultaneous electrical and mechanical interactions of 240-cells and 548-links were considered. Electrophysiological interactions of cells through ion channels with the extrascellular environment and gap junctions with adjacent cells lead to the production and propagation of slow waves in smooth muscle. This wave causes contraction and peristaltic movements in the muscles of the gastric wall. By blocking calcium and potassium ionic channels by pharmacological agents can be improved disorders caused by these movements and contractions and brought them closer to the physiological state.


Main Subjects

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